Veja grátis o arquivo ATLAS DE HEMATOLOGIA (McDONALD) enviado para a disciplina de Hematologia Categoria: Aulas – 18 – Atlas de hematologia, – ,-~,. 1r6logo (Ie b pl”imcra t,-dicioll_ _ Prcfacio de b quinta ec:lici6n._ _ Prcf{lcio de ]a pl;mcra edicibn t. “. Title, Atlas de hematología. Authors, George A. McDonald, J. Paul, Bruce Cruickshank. Edition, 5, illustrated, reprint. Publisher, Médica Panamericana,

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Manual of clinical hematology. All the contents of this journal, except where otherwise noted, is licensed under a Creative Commons Attribution License. Services on Demand Journal. Let’s connect Contact Details Facebook Twitter. The ruptured lymphocytes, stained in pink, show themselves irregular and constitute the Gumprecht shadows Transient cookies are kept in RAM and are deleted hemarologia when you close all your browser windows, or when you reboot your computer.

Although more sophisticated methods, such as flow cytometry and cytogenetics, hematolgia currently used to refine this diagnosis 29the initial suspicion comes from cell morphology observed atoas the blood film.

Gumprecht shadows: when to use this terminology?

The inappropriate use of this term may cause atpas anxiety in individuals who receive this observation in their blood count, as well as to their families, since information on the internet is available to any person and is frequently used to clear doubts on medical terms. Cytogenetics helps to detect abnormalities,especially in chromosomes 11 and The expression Gumprecht shadows must be used only for cases of CLL, not to describe ruptured hematologiz present in other situations with lymphocytosis, associated with either viral diseases or other causes.

Cookies come in two flavours – persistent and transient. In a web search engine commonly used to clear doubts on medical terms, there are countless pages where Gumprecht shadows are associated with CLL.


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However, only the morphological aspects d lymphocytes do not allow differentiation between B- and T-CLL type. Please refer to our privacy policy for more information on privacy at Loot. Blood Cellsv. Most of the times, CLL is unexpectedly diagnosed by a hmeatologia blood test. Inappropriate use of this term can cause great anxiety in individuals receiving their blood count results, as well as in their families. World Health Organization classification of tumours of haematopoietic and lymphoid tissues.

Email address subscribed successfully. It is known that viral conditions present with a high number of circulating lymphocytes, which are also susceptible to lysis.

Bruce Cruickshank (Author of Atlas de hematologia)

Since the presence of viroses may cause the appearance of images similar to those observed in CLL because of lymphocyte lysis, a literature review was undertaken by searching the word Gumprecht referring to images of lymphocyte lysates that occur in viral diseases.

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In this case, lymphocytosis occurs when old cells accumulate, because the apoptosis mechanism is impaired Ann Biol Clinv. Cookies are little nuggets of information that web servers store on your computer to make it easier for them to keep track of your browsing session.

CLL is suspected when the blood film reveals an expressive increase in uniform-appearing lymphocytes and the presence of destroyed lymphocytes.

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Annales de Biologie Cliniquev. ESMO clinical practice guidelines for diagnosis, treatment and follow-up. Escola paulista de medicina.

After a thorough and careful search, only a doctoral dissertation was found, in the area of Veterinary Medicine, where this term was used The microscopic examination of blood cells is surely an essential step for the diagnosis of CLL: Thus, the most frequently used textbooks in English or Portuguese5,15,in our setting do not refer to this term, although older literature values Gumprecht shadows for the diagnosis of CLL.


The World Health Organization WHO describes CLL as a neoplasm of small B lymphocytes, with slightly irregular membrane present in peripheral blood, bone marrow, spleen and lymph nodes, along with prolymphocytes and paraimmunoblasts that proliferate in the infiltrated tissues Annals of Oncologyv.

In CLL, this process is due to cell aging. Flow cytometry allows identification of cluster differentiation CD specific to B lymphocytes CD14, CD20, and CD23 and, as a result, characterizes the clonal origin of these lymphocytes In face of the ambiguous use of the term Gumprecht shadows in clinical situations of distinct prognosis and evolution, it would be quite pertinent to keep using it in cases of CLL, principally knowing that absolute lymphocytosis in peripheral blood is not always a sign of malignancy.

Subscribe to our newsletter Some error text Name. We never store sensitive information about our customers in cookies. To the nucleolar bodies nucleoli in cells of the lymphocytic lineage in patients suffering from B-chronic lymphocytic leukemia.


Besides, serum determination of lactate dehydrogenase LDHbilirubin, immunoglobulins, and antiglobulins composes the test panel currently used to diagnose CLL 6.

Since hyperplasia of lymphoid tissues and lymphocytosis may occur in other infectious processes, especially viral diseases, and in chronic inflammatory processes, such as arthritis, lupus erythematosus, vasculitis, sarcoidosis, etc.

In the blood film, lymphocyte lysates, resulting from viral infection, present similar aspects to those described by Gumprecht to refer mcdonzld lymphocyte lysates at CLL On the other hand, in lymphomas, although cells express B-lymphocyte and CD5 surface antigens, they normally do not express CD The serum levels of immunoglobulins CD20 and CD79b are significantly reduced in comparison to normal B-lineage cells.

CLL is a relatively rare lymphoproliferative disorder. Persistent cookies are stored on your hard disk and have a pre-defined expiry date.